Benefit of Magnesium Bisglycinate: Is It the Same as Magnesium Glycinate and Why Add Vitamin K2 & D3? | Trio Nutrition

magnesium compounds like glycinate and bisglycinate

The information in this article and throughout Trio Nutrition’s blog is for informational purposes only and should not replace professional medical advice.

Magnesium Bisglycinate vs. Magnesium Glycinate: What’s the Difference?

The terms magnesium bisglycinate and magnesium glycinate are often used interchangeably—and in most cases, they are the same. However, there’s a slight difference worth noting.

Magnesium bisglycinate is the more accurate term. The prefix “bis-” means two, which means one magnesium ion is chelated (or bonded) to two molecules of the amino acid glycine. This structure helps improve intestinal absorption, making it a popular choice among magnesium supplements for those looking to maintain healthy magnesium levels.

Magnesium glycinate, on the other hand, is a broader term that usually refers to the same chelated form, but in some cases, it could describe blends that aren’t fully chelated.

Both names generally refer to a magnesium form that is highly bioavailable and gentler on digestion compared to other forms of magnesium, such as magnesium oxide or magnesium salts.

Why Magnesium Matters for Your Health

Magnesium is an essential mineral involved in more than 300 biochemical reactions in the body. This essential mineral plays a key role in:

  • Normal muscle and nerve function

  • Energy production and protein synthesis

  • Healthy blood pressure regulation and blood sugar levels

  • Bone health and overall wellness

A lack of dietary magnesium intake over time can lead to magnesium inadequacy, which may affect muscle function, sleep quality, and energy levels. Symptoms like muscle cramps, muscle weakness, or even migraine headaches can be linked to low dietary intake of magnesium, an essential mineral. It may also increase the likelihood of developing conditions such as high blood pressure over time.

Should you take magnesium? Although a healthy diet with green leafy vegetables, nuts, and whole grains can help, 48% of people do not meet the recommended dietary allowance. That’s why you should take supplemental magnesium. Magnesium supplementation is often considered for supporting muscle and nerve function, healthy sleep, and overall well-being. With so many forms of magnesium available, it’s important to know which supplemental magnesium best supports your health goals.

Why Choose Magnesium Glycinate (Magnesium Bisglycinate) Over Other Forms of Magnesium

There are many magnesium forms, including magnesium citrate, magnesium malate, and magnesium oxide. However, as per National Institute of Health (NIH), magnesium glycinate supplements stand out in these areas:

  • Have high bioavailability for better absorption

  • Are gentle on digestion mitigating digestive discomfort compared to other magnesium salts

  • Help support muscle relaxation, normal muscle function and recovery, healthy sleep quality, and nerve function

If you’re thinking of increasing your magnesium intake with magnesium supplements, remember to stay within the tolerable upper intake level from supplements and medications (see guidelines established by the research and published by NIH for tolerable upper intake levels to avoid too much magnesium).

Taking extra magnesium or high does may in some instances cause abdominal cramping or diarrhea. But, this particular side effect of high doses is generally mitigated with the use of supplements contain magnesium glycinate versus other forms of magnesium. You should always consult consult your physician or healthcare provider prior to taking any supplements including taking magnesium supplements.

As you may be aware, there are many magnesium supplements in the marketplace; however, if you are interested in taking magnesium supplements and a blend of magnesium, not restricted only to magnesium glycinate, you may want to consider Trio Nutrition’s Magnesium Complex, which offers enough magnesium, 420 mg or how much magnesium is required for 100% recommended dietary allowance of elemental magnesium, and a full 90-day supply per bottle.

Why Add Vitamin K2 and D3?

Magnesium alone is important, but Magnesium benefits become even stronger when paired with Vitamin K2 and Vitamin D3. These three nutrients complement each other to support bone health, healthy calcium balance, and immune function, creating a more complete approach to wellness.

Vitamin K2: An Underrated Nutrient

Vitamin K2 helps ensure calcium goes where it belongs—into your bones and teeth—while reducing the chance of it collecting in soft tissues like arteries. This supports both bone health and cardiovascular health.

While you can find Vitamin K2 in foods like fermented dairy products and Natto (fermented soybeans), it’s not always easy to get enough from diet alone. Adding dietary supplements that include K2 may help maintain healthy bones, nerve and muscle function as well as proper calcium use.

Vitamin D3: The Sunshine Vitamin

Vitamin D3 works with magnesium to assist in calcium absorption and bone density maintenance. It also supports a healthy immune system and neuromuscular function.

Although sunlight helps your body produce Vitamin D3 naturally, factors like limited sun exposure and sedentary lifestyle habits can make it difficult to maintain adequate intake. Supplementation is often recommended to ensure healthy vitamin D levels and overall balance.

When these three nutrients work together, their synergistic combined benefits go beyond what each can offer alone.

Read More: Vitamin D vs D3: What’s the Difference?

The Power of Combining Magnesium, K2, and D3 Dietary Supplements

Together, these nutrients can help with:

  • Supporting better sleep quality

  • Strong, healthy bones and teeth

  • Normal muscle health, mitigating muscle cramps, supporting muscle recovery and nerve function

  • Better sleep quality

  • Energy production

  • A healthy immune system

This synergy of dietary supplements makes them an excellent combination for supporting overall health, especially if you want to optimize your magnesium status while enhancing bone health and muscle function. Along with supplemental magnesium, K2, D3, adding nutrient-rich foods to your diet is another way to support your health.

Food Sources of Magnesium, K2, and D3

magnesium food sources
  • Magnesium: Green leafy vegetables like spinach and kale, nuts (almonds, cashews), seeds (pumpkin, chia), whole grains, and legumes

  • Vitamin K2: Fermented foods such as natto (fermented soybeans), certain cheeses (Gouda, Brie), yogurt, egg yolks, and organ meats

  • Vitamin D3: Fatty fish like salmon, mackerel, and sardines, egg yolks, liver, and fortified milk or cereals (of course, sunlight exposure remains one of the best ways to boost Vitamin D3 levels)

Even with a healthy diet, reaching your adequate intake for these nutrients can be challenging. So if you are considering taking magnesium glycinate supplements, why not take magnesium glycinate supplements combined with Vitamin K2 and D3 is a convenient option for many people to avoid magnesium deficiency.

Trio Nutrition’s Magximum: All-in-One Support

trio nutrition with magnesium bisglycinate

If you want to experience the health benefits of four essential nutrients in one formula, try Trio Nutrition’s World Famous Magximum. It is more than just taking magnesium glycinate supplements. Magximum is the first magnesium glycinate supplement that also includes Vitamin K2, Vitamin D3, and MCT Oil Powder—all in a vegetarian capsule.

This combination is designed to help support:

  • Healthy bones and bone density

  • Normal muscle function, muscle recovery and normal nerve activity

  • Restful sleep and mental health balance

  • Energy production

  • A healthy immune system

Magximum is manufactured in the United States. Therefore, the Food and Drug Administration (FDA) provides oversight into several key aspects of quality control, primarily through its regulation of dietary supplements. Try Trio Nutrition's Magximum today with our 60-day risk-free money-back guarantee and experience the difference in your daily wellness.


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