Magnesium Glycinate Supplements

Magnesium glycinate is not among the forms the NIH Office of Dietary Supplements names as most commonly reported to cause diarrhea, which are magnesium carbonate, chloride, gluconate and oxide. The NIH Office of Dietary Supplements explains that the laxative effect of magnesium salts comes from the osmotic activity of unabsorbed magnesium in the intestine and colon, and that high doses from supplements can cause diarrhea, nausea and abdominal cramping. Loose stools are a signal to review the total magnesium taken from all supplements. Anyone with ongoing digestive changes should speak with a healthcare provider.*

Magnesium glycinate is chelated to the amino acid glycine, which makes magnesium glycinate one of the best-absorbed and gentlest forms, while citrate is well absorbed but more laxative and oxide is only about 4% absorbed and mostly used for occasional constipation. Trio Nutrition uses magnesium glycinate — 210 mg in Magximum and 420 mg with oxide in Magnesium Complex — for daily calm, sleep, and muscle support. The best form depends on the goal and personal tolerance.*

About 50% to 60% of the magnesium in an adult body is stored in bone, according to the NIH Office of Dietary Supplements, out of a total of roughly 25 grams. Most of the remaining magnesium sits in soft tissues, and less than 1% circulates in blood serum, which is why a serum test does not fully reflect total magnesium status. Magnesium is a cofactor in more than 300 enzyme systems, including systems involved in protein synthesis and muscle and nerve function. Adults comparing magnesium products against the NIH recommended intake of 310 to 420 mg per day from all sources can read the elemental magnesium figure on each Trio Nutrition panel.*

The Daily Value for magnesium is 420 mg. The NIH Office of Dietary Supplements notes that high intakes of magnesium from supplements can cause diarrhea, nausea and abdominal cramping, which is the body's signal to cut back. Anyone with kidney concerns should be especially careful and consult a healthcare provider.*

Magnesium glycinate can interact with some medications, because the NIH Office of Dietary Supplements reports that magnesium forms insoluble complexes with tetracycline and quinolone antibiotics. The NIH Office of Dietary Supplements advises taking those antibiotics at least 2 hours before or 4 to 6 hours after a magnesium supplement, and separating oral bisphosphonates from magnesium-rich supplements by at least 2 hours. Magximum also contains vitamin K2 as MK-7, and the NIH Office of Dietary Supplements notes that vitamin K can lower the effectiveness of the blood thinner warfarin. Anyone taking prescription or over-the-counter medicines should consult a healthcare professional before taking magnesium glycinate or any other dietary supplement. A pharmacist can confirm safe timing for any prescription routine.*

For healthy adults, daily magnesium supplements are taken at the label serving unless a healthcare provider recommends more. Magnesium is an essential mineral, and the NIH recommended intake from all sources is 400 to 420 mg per day for men and 310 to 320 mg per day for women. The NIH Office of Dietary Supplements reports that the diets of many people in the United States provide less magnesium than recommended. Anyone who is pregnant, nursing or living with a kidney condition should confirm long-term use with a healthcare provider first.*

Yes. Trio Nutrition magnesium is Manufactured in the USA in FDA-registered, GMP-certified facilities and is lab tested for quality. The NIH Office of Dietary Supplements notes that Supplement Facts panels declare elemental magnesium rather than the weight of the whole compound, so the Magnesium Complex figure of 420 mg at 100% of the Daily Value refers to magnesium itself. Magnesium Complex combines magnesium glycinate and magnesium oxide with 2 mg of vitamin B6, and both magnesium formulas use vegetarian capsules made without major food allergens. Adults comparing magnesium products can use the elemental figure on each panel to compare servings directly.*

Magnesium glycinate during pregnancy or breastfeeding is a decision for a healthcare provider, because the NIH Office of Dietary Supplements advises caution with dietary supplements beyond a standard prenatal supplement while pregnant or nursing. The NIH recommended magnesium intake from all sources is 350 to 360 mg per day for pregnant adults and 310 to 320 mg per day for breastfeeding adults. Magnesium glycinate is a chelated form in which magnesium is bound to the amino acid glycine. Anyone pregnant or breastfeeding should speak with a healthcare provider before starting any magnesium supplement.*