Magnesium Glycinate Supplements

Trio Nutrition Magnesium Complex — 420 mg magnesium glycinate with Vitamin B6, 3-month (90-day) supply, Manufactured in the USA
Magnesium Complex – Magnesium Glycinate with Vitamin B6
$39.95
Trio Nutrition Magximum bottle — magnesium glycinate with D3, K2 and MCT oil, Manufactured in the USA
Magximum™ – Magnesium Glycinate with D3, K2 & MCT Oil
$44.95

Trio Nutrition's magnesium glycinate supplements provide a highly bioavailable, chelated form of magnesium designed for maximum absorption and superior digestive tolerance. Bound to the amino acid glycine, our formulas stay gentle on the stomach while supporting deep muscle relaxation, nighttime rest, and everyday stress management.

Which magnesium is right for you?

  • Magximum — targeted evening relaxation & sleep; chelated magnesium glycinate with Vitamin D3, K2, and MCT oil.
  • Magnesium Complex — high-dose daily replenishment; 420 mg (100% DV) with Vitamin B6.

The Science of Chelated Magnesium Glycinate

Magnesium glycinate stands out in nutritional science due to its molecular stability. By bonding elemental magnesium with two molecules of glycine, the mineral bypasses standard competitive pathways in the digestive tract, which is why it is far less likely to cause the loose stools associated with magnesium oxide.

Targeted muscle and sleep support. Once absorbed, magnesium serves as an essential cofactor in over 300 enzymatic reactions, aiding neurological calm by supporting normal neuromuscular function and the body's natural sleep architecture.

Reviewed by Trio Nutrition Wellness Team | Last Updated: July 2026

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Frequently asked questions

Does magnesium glycinate cause diarrhea or loose stools?

Magnesium glycinate is one of the gentlest forms on the stomach because the magnesium ion is chelated to the amino acid glycine, making magnesium glycinate far less likely to cause the loose stools that magnesium oxide and citrate can trigger. Magnesium glycinate is absorbed across the intestinal wall rather than drawing water into the bowel, which is why people with sensitive digestion often choose the glycinate form. If loose stools do occur, lowering the serving of magnesium glycinate — 210 mg in Magximum — usually resolves the issue.

Which form of magnesium is best absorbed: glycinate, citrate, or oxide?

Magnesium glycinate is chelated to the amino acid glycine, which makes magnesium glycinate one of the best-absorbed and gentlest forms, while citrate is well absorbed but more laxative and oxide is only about 4% absorbed and mostly used for occasional constipation. Trio Nutrition uses magnesium glycinate — 210 mg in Magximum and 420 mg with oxide in Magnesium Complex — for daily calm, sleep, and muscle support. The best form depends on the goal and personal tolerance.

How long does magnesium glycinate take to work?

Timing depends on the goal: muscle relaxation and calm may be noticed within the first few days, while benefits tied to steady magnesium status build over 2 to 4 weeks of daily use as magnesium is absorbed and stored. Magnesium serves as a cofactor in more than 300 enzymatic reactions, so the body maintains magnesium over time and consistency matters more than any single dose. Individual results vary with diet, baseline magnesium levels, and lifestyle.

Can you take too much magnesium glycinate in a day?

The Daily Value for magnesium is 420 mg, and the National Institutes of Health notes a tolerable upper limit of 350 mg per day for magnesium from supplements specifically, while magnesium from food is not capped. Taking more than needed can cause loose stools or cramping, which is the body's signal to cut back. Anyone with kidney concerns should be especially careful and consult a healthcare provider.

Does magnesium glycinate interact with any medications?

Magnesium can bind certain medications and reduce absorption, including some antibiotics such as tetracyclines and quinolones plus bisphosphonates, so those medications are usually taken 2 to 4 hours apart from magnesium. Because Magximum also contains vitamin K2 as MK-7, anyone on a blood thinner such as warfarin should check with a doctor first. A pharmacist can confirm safe timing for any prescription routine.

Is it safe to take magnesium glycinate every day, long term?

Magnesium is an essential mineral the body needs daily, and a 420 mg serving simply meets 100% of the Daily Value, so ongoing daily use is appropriate for most healthy adults. The glycinate form's gentle absorption makes it well suited to long-term routines. Anyone who is pregnant, nursing, or living with kidney disease should confirm with a healthcare provider first.

Is Trio Nutrition magnesium glycinate lab tested and manufactured in the USA?

Yes. Trio Nutrition magnesium is Manufactured in the USA in FDA-registered, GMP-certified facilities and is lab tested for quality. The vegetarian capsules are made without major allergens, and every order carries a 60-day, 100% money-back guarantee. Trio Nutrition has been trusted by more than 250,000 households since 2018.

Is magnesium glycinate safe to take during pregnancy or breastfeeding?

Magnesium is an essential mineral that remains important during pregnancy, with a recommended intake near 350 to 360 mg per day, and glycinate is a well-tolerated chelated form, though individual needs vary. Trio Nutrition recommends that anyone pregnant or breastfeeding speak with a healthcare provider before starting any supplement. A provider can confirm the right dose alongside a prenatal routine.